An oral care preventive solution

See video


Oral health is a crucial aspect of general health. Traditional oral care solutions act after bacterial dental plaque has already started to form, although the damage may have occurred already. Biolocker is a solution based on a new approach that acts before the plaque has started to form, before any of the initial damage is caused.


  • To develop an oral care tool that prevents early bacterial dental plaque formation by blocking key bacterial interactions that promote the early development of dental plaque, which leads to dental caries and other damage.

Problem to Solve

2.5 billion people (37% of world’s population) suffer from dental caries. In addition, several periodontal diseases affect a significant number of people worldwide.

Most of these diseases are preventable with oral care solutions, and do not require expensive treatments. However, prevention solutions are scarce, and most oral care products act only for a limited time after their application, when damage has already started.


Two organic molecules have been designed to block early key bacterial interactions and they have been shown to be effective in preventing dental plaque accumulation in both preliminary and advanced tests. Biolocker is designed to be applied after brushing your teeth, but its protection will last during a broader time window than any oral care product currently in the market. This will significantly improve existing oral care prevention solutions.

Level of Innovation

Biolocker is a versatile solution that can be implemented in many forms (mouthwash, toothpaste). Its application will provide unpaired protection during the day and directly impact on the possibility of developing plaque related diseases.


Project leader. Product developer and assistant professor at Universidade de Coimbra

Filipe Antunes

Universidade de Coimbra

Project leader

Project coordinator

Daniel Abegão

Universidade de Coimbra

Scientific coordinator

Tiago Santos

Universidade de Coimbra

Medical coordinator

Sergio Matos

Universidade de Coimbra

Product engineer

Gabriela Martins

Universidade de Coimbra

Associate medical researcher

Inês Fernandes

Universidade de Coimbra


Research Director

Clara Campàs

Kern Pharma SL


Obra social “la Caixa”
Caixa Capital Risc

Scientific Area

Biochemistry and Molecular biology

Business area

Medical Devices

Research center

Universidade de Coimbra