CoverGel A new tool for managing therapeutic endoscopy complications

  • Edition: 2018
  • Research center: Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol
  • Scientific Area: Surgery
  • Business area: Medical Devices
  • Status: In development
  • Contact: vlorenzo.germanstrias@gencat.cat

Therapeutic endoscopy is a procedure used increasingly to treat several digestive diseases. However, endoscopies that involve mucosal resection or submucosal dissection, such as therapeutic colonoscopies, are associated with harmful complications such as bleeding or perforations in the 15% of cases.

Goals

  • To make progress towards producing CoverGel, a topical hydrogel for endoscopic therapeutic interventions that prevents the complications that arise from thermal damage to the intestinal mucosa.

Problem to Solve

Up to 16.5 million therapeutic colonoscopies are performed annually around the world. In colorectal cancer, the use of resection techniques allows for polyp removal, reducing the need for surgical intervention. Nonetheless, electrocautery is still needed to perform resection techniques, which increases the rate of bleeding or perforations. This highlights the urgent need to find new methods that can reduce such complications.

 

Innovation

CoverGel is a new hydrogel that prevents the complications associated with resection techniques in therapeutic colonoscopies. It is a biocompatible, biodegradable and bioactive compound, and can be applied directly to the mucosal layer using the endoscope, or via a submucosal injection.

Level of Innovation

CoverGel has shown robust healing effects in porcine preclinical models. It is a patented medical device that shows the potential to be used while treating colorectal cancer.

Team

Project leader

Vicente Lorenzo-Zúñiga

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

Senior Researcher. Chief Scientific Officer

Ramon Bartolí

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

PhD student

Ignacio Bon

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

Innovation and Technology Transfer Manager

Marc Cusachs

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

Mentor

Global Product Marketing Manager

Raúl Zurita

B. Braun España

Partners

Obra social “la Caixa”
Caixa Capital Risc