New predictive biomarkers of functional recovery prior to endovascular treatment of acute ischemic stroke

Research

The rate of significant functional disability or death after an acute ischemic stroke ranges from 40% to 67%. Early cortical response (N20) from somatosensory evoked potentials (SEPs), i.e. the electrical activity of the brain that results from the stimulation of touch, could act as a predictive factor of good functional outcome in patients undergoing mechanical thrombectomy (MT).

Aim

  • To develop an automatic computational method for N20 recording, which would be implemented in a pocket device that also enables SEPs recording. This will speed up streamline decision-making regarding who could benefit from MT.

Problem to Solve

In the last two decades, there have been major advances in the field of stroke therapeutics such as the endovascular treatment (intraarterial thrombolysis or mechanical thrombectomy). Nowadays, multiple predictive factors of neurological outcome after reperfusion treatment have been reported, based on clinical and neuroimaging variables. Nonetheless, the rate of significant functional disability or death after three months of an acute ischemic stroke still ranges from 40% to 67%. Thus, it is crucial to develop new predictive factors based in neurophysiological criteria to improve neurological outcome after these therapies.

Innovation

Early cortical response (N20) from somatosensory evoked potentials (SEPs) has been used as a neurophysiological test for years. There is also clinical and experimental evidence of the correlation between SEPs and cerebral blood flow. Recently, the PROMISE study first described that N20 could act as a predictive factor of good neurological outcome in patients undergoing mechanical thrombectomy (MT) after an acute ischemic stroke.

The development of a pocket device for sanitary staff to record SEPs will provide early data about N20 value, speeding up streamline decision-making on who should be directly transferred to a comprehensive stroke center for MT.

Team

Project leader. Head Neuromuscular Unit

Alicia Martínez Piñeiro

University Hospital Germans Trias i Pujol

Project leader

General director. Director Neurosciences Department

Antoni Dávalos Errando

University Hospital Germans Trias i Pujol

Neuromuscular Unit. UAB Associate Professor

Jaume Coll-Cantí

University Hospital Germans Trias i Pujol

Innovation and Business Development Manager

Marc Cusachs Farraro Cusachs Farraro

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

MENTOR

ICREA Research Professor and Co-founder

Roger Gomis

Inbiomotion SL

Partners

Obra social “la Caixa”
Caixa Capital Risc
Validate-19

Scientific Area

Neurosciences

Business area

Medical Devices

Research center

Germans Trias i Pujol Research Institute