Molecular tool to diagnose endometrial cancer

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CEMARK is an innovative, patented and non-invasive diagnostic tool for endometrial cancer (EC), based on the detection of protein biomarkers in uterine fluid.

Endometrial Cancer represents the seventh most deadly type of cancer in women in developed countries. Early and accurate detection of neoplastic growths are hallmarks of improved survival. Moreover, the current paradigm involves several rounds of tedious, subjective and invasive rounds of diagnosis. Thus, a reliable and objective diagnosis tool would greatly improve women’s life and reduce unnecessary healthcare expenditures associated with overdiagnosis.


  • To develop a routine clinical test that will correctly diagnose patients with endometrial cancer in women that present abnormal vaginal bleeding.

Problem to Solve

Endometrial cancer symptoms are not very specific, namely abnormal vaginal bleeding (AVB). However, only 5-10% of women with AVB further develop EC. Therefore many women are subjected to a tedious, subjective and minimally-invasive process, which in 22% of cases need from additional invasive testings. On top of that, interobserver variability in pathological interpretation leads up to 55% incorrect staging. This inefficient diagnostic process has several consequences, from life expentancy and patient’s quality of life to associated healthcare costs. 


CEMARK is based in the analysis of a set of protein biomarkers in uterine fluid, obtained from pipelle biopsies, providing accurate diagnosis to women with abnormal vaginal bleeding.

Level of Innovation

CEMARK will provide a more reliable and sensitive diagnosis of EC, reducing the current overdiagnosis. Moreover, its design as an ELISA kit will facilitate its clinical implementation. 


Project leader. Postdoctoral researcher

Eva Colás Ortega

Vall d’Hebron Institute of Research

Project leader

Head of the Gynecology Department & Head of Biomedical Research Group in Gynecology

Antonio Gil

Vall Hebron University Hospital

Ph.D. student

Elena Martínez

Vall d’Hebron Institute of Research



Andrés G. Fernández

Ferrer Advanced Biotherapeutics


Obra Social
Caixa Capital Risc

Scientific Area

Clinical sciences

Business area


Research center

Vall d'Hebron Institut de Recerca