Therapeutic endoscopy is a procedure used increasingly to treat several digestive diseases. However, endoscopies that involve mucosal resection or submucosal dissection, such as therapeutic colonoscopies, are associated with harmful complications such as bleeding or perforations in the 15% of cases.
- To make progress towards producing CoverGel, a topical hydrogel for endoscopic therapeutic interventions that prevents the complications that arise from thermal damage to the intestinal mucosa.
Problem to Solve
Up to 16.5 million therapeutic colonoscopies are performed annually around the world. In colorectal cancer, the use of resection techniques allows for polyp removal, reducing the need for surgical intervention. Nonetheless, electrocautery is still needed to perform resection techniques, which increases the rate of bleeding or perforations. This highlights the urgent need to find new methods that can reduce such complications.
CoverGel is a new hydrogel that prevents the complications associated with resection techniques in therapeutic colonoscopies. It is a biocompatible, biodegradable and bioactive compound, and can be applied directly to the mucosal layer using the endoscope, or via a submucosal injection.
Level of Innovation
CoverGel has shown robust healing effects in porcine preclinical models. It is a patented medical device that shows the potential to be used while treating colorectal cancer.